Calea zacatechichi may cause vivid imagery, disorienting effects, and hallucinations. Calea zacatechichi is a plant used by the Chontal Indians of Mexico to obtain divinatory messages during dreaming. At human doses, organic extracts of the plant produce the EEG and behavioral signs of somnolence and induce light sleep in cats. Calea zacatechichi is also used for the following conditions: Anxiety Appetite stimulation Arthritis Asthma Cleansing Constipation Diabetes Diarrhea, Digestive disorders Dysentery Fever Headache Inflammation Joint problems Malaria Menstrual problems …

Stomach disorders : When smoked or consumed in a tea, Calea zacatechichi may cause nausea, vomiting, and retching. Large doses elicit salivation, ataxia.

The objective of this work was to determine the toxic effect in vivo and in vitro of the aqueous extract of Calea ternifolia (C. zacatechichi), known popularly as “dream herb”. retching and occasional vomiting.
For instance, some states, such as Lousiana State, stated that it is illegal to possess if it is meant for human consumption, but not if they are intended for ornamental or landscaping use. Calea Zacatechichi is legal almost everywhere, however, there are small exceptions. “Dream herb,” Calea zacatechichi, has long been used in traditional folk medicine for a variety of purposes and is currently being marketed in the US for medicinal purposes, including diabetes treatment. Despite the inherent vulnerability of the renal system to xenobiotic toxicity, there is a lack of safety studies on the nephrotoxic potential of this herb.

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